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Ketoconazole Coadministration of bosentan 125 mg 2 times everyday and ketoconazole, a potent CYP3A inhibitor, greater the plasma concentrations of bosentan by about a hundred% in standard volunteers. No dose adjustment of bosentan is necessary, but elevated consequences of bosentan need to be viewed as.Bosentan and Ro forty eight-5033 are actually